One of the most important challenges of the hydrogen peroxide technology has traditionally been the material compatibility. The high oxidation potential of the compound is the main driver of the microorganism deactivation, but it is also, in some cases, the main driver of the damage that the materials could undergo when treated with this chemical. This study has demonstrated that, even though there is oxidation in materials such as copper or POM, the most common materials found in the pharmaceutical industry are not affected by a low concentrated solution. It emphasizes the importance of the type of injection technology as well as the sterilant formulation when discussing about hydrogen peroxide material compatibility.