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Project

Process installations for Parenteral Serums Plant

Location

Rubi, Spain

Description

TurnKey Project

Pharmaceutical manufacturing and process facilities for parenteral solutions in the new 30,000sqm LIFT (Lean Infusion Factory Technology) plant at the Group’s production center located in Rubí (Barcelona), Spain, which features three production lines.

Telstar handled the project management under an EPC (Engineering, Procurement and Construction).

The firm developed the engineering phases, coordinated all involved vendors, built the pharmaceutical manufacturing and process facilities, supplied the equipment and performed start-up and validation.

The facilities were designed for a continuous production process, have four 30,000-litre manufacturing tanks, and two additional 15,000-litre tanks, to feed three bottling lines with 24/7 production capacity. Design, installation, start-up and validation of manufacturing tanks with magnetic stirring and interior product recirculation, which ensure a uniform and aseptic production. For the tank loading system, a critical phase of the process, Telstar implemented a custom, bin-to-tank product transfer system, using ‘Alpha/Beta‘-type high containment valves.

In addition to the tanks, Telstar installed the transfer lines from the reactors to the bottling equipment, featuring blow-fill-seal technology and terminal filter systems.

Telstar supplied the weighing booths and Special Airlock Systems (SAS) for materials pass-through and unloading bins, as well as a specially configured bin washer.

The pharmaceutical manufacturing and process facilities operate automatically, including management of weighing, in-tank preparation management, traceability of bins in the LIFT manufacturing room, and interconnections to the new plant’s other automated systems.

Scope

  • Concept, Basic, Detailed Design
  • EPC Contractor
  • Process Systems & Equipment
  • Weighing & Sampling Booths